• Basis. Clinically proven to boost NAD+ by 40%. Promotes cellular energy, reducing general tiredness and fatigue. Supports healthy aging by maintaining hundreds of processes in your cells. Developed by our chief scientist and leading aging researcher Leonard Guarente, Ph.D.
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  • Supplement Facts[text in image]Supplement Facts
  • TIME magazine's longevity issue says Basis is "the supplement experts take."
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Basis

Basis

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Description

Power up the powerhouse of your cells. Signal is designed to target metabolic aging by protecting mitochondria—where the energy in your cells is made. Increase NAD+ with the precursor NMN to support energy production and activate SIRT3, a key mitochondrial enzyme, to protect and generate new mitochondria and help your cells adapt to daily metabolic changes as you age.

  • Increase levels of the critical coenzyme NAD+ by 40% via the highly efficient precursor NMN
  • Activate sirtuin 3 (SIRT3) to protect and generate new mitochondria to support cellular metabolism and energy
  • Help maintain healthy insulin sensitivity in muscle—essential to maintaining blood sugar levels
  • Support vascular health—critical for your athletic endurance 
  • Support brown fat thermogenesis, a cellular process which converts sugar and fat into heat to help maintain body temperature and support a healthy metabolism
  • Reduce general tiredness and fatigue, support healthy muscle function, and feel good for your age

Ingredients

Signal contains two ingredients that work synergistically to support metabolic health:

  • Nicotinamide Mononucleotide, NMN (250mg)
    NMN is a highly efficient precursor of the coenzyme nicotinamide adenine dinucleotide (NAD+), which is central to creating cellular energy and performing other key metabolic functions.
  • SIRT3 Activation Complex (150mg)
    Supports healthy mitochondrial function through a combination of honokiol (isolated from the bark of Magnolia officinalis), and viniferin (derived from grapevines). Both honokiol and viniferin are potent activators of SIRT3, a metabolic enzyme found in the mitochondria that helps preserve existing as well as generate new mitochondria.
  • Vegetarian, vegan, gluten-free, nut-free, and contains no artificial colors or flavors.
  • NSF Certified for Sport, the only independent third-party certification program recognized by the United States Anti-Doping Agency (USADA).

Recommended Use

  • Take two capsules every morning, with or without food.
  • Each bottle contains a 30-day supply.
  • This product is only intended for healthy adults. Do not take if you are pregnant or nursing. Consult with your physician before using.
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Your Metabolism Ages Too

Metabolism converts food into the energy you need for life. As you age, your metabolism slows and becomes less efficient—impacting how quickly and effectively your cells function. 

This happens for two main reasons: First, levels of a coenzyme called NAD+, which is central to hundreds of metabolic processes and cellular energy production, decline. Second, enzymes inside our mitochondria—the powerhouses of our cells—like SIRT3 that depend on NAD+ to function slow down.

How to Target Metabolic Aging in Your Cells

Signal restores the age-related decline in NAD+ levels with NMN, one of the most efficient precursors of NAD+. A human clinical study demonstrated that 30 days of NMN supplementation at 250mg/day resulted in a 40% increase in NAD+ levels in the blood. NMN supplementation has been shown to support insulin sensitivity, vascular health (critical for athletic endurance), and muscle function.